Russell Westbrook scored 29 points, Kevin Durant had 25 and Serge Ibaka added 12 for the Thunder, who suffered their worst home loss since moving to Oklahoma City.
The Clippers scored 23 points off Oklahoma City's 18 turnovers.
Game 2 is Wednesday night in Oklahoma City.
Both teams were coming off Game 7 wins in the first round on Saturday night.
Oklahoma City opened by taking a 16-10 lead but the Clippers responded with a 24-6 run. Paul hit five 3-pointers in the first quarter, matching his career high for 3s in a playoff game in the first 12 minutes. The Clippers shot 67 percent in the first quarter to take a 39-25 lead.
Los Angeles extended its lead to 24 points in the second quarter and took a 69-52 halftime lead with Paul getting 22 points and six assists.
Durant and Westbrook scored 16 points each in the first half, but the Thunder committed 11 turnovers before halftime.
A quick 3-pointer and a pull-up jumper by Paul pushed the Clippers' lead to 78-56 in the opening minutes of the third quarter. The Clippers reached 100 points with just over a minute left in the period and led 104-78 heading into the fourth quarter.
NOTES: Oklahoma City G Thabo Sefolosha rejoined the starting lineup after sitting out the final two games against Memphis. Thunder coach Scott Brooks said before Monday's game that he started Caron Butler in Games 6 and 7 against Memphis because the team needed another offensive weapon. ... Clippers F Blake Griffin attended the University of Oklahoma. He got a mixed reaction during pregame introductions. ... The Clippers made 7 of 10 3-point attempts in the first quarter. ... Ibaka was issued a technical foul in the third quarter after getting his legs tangled up with Griffin. ... Clippers C DeAndre Jordan made just 1 of 8 free throw attempts. ... Durant was issued a technical foul for arguing with an official with 10:40 remaining in the fourth quarter. ... The Clippers committed just nine turnovers.
Source: si.com by Cliff Brunt